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NEUROLOGY 2004;62:1963-1966
© 2004 American Academy of Neurology

APOE influences on neuropsychological function after mild head injury

Within-person comparisons

A. Sundström, MS, P. Marklund, MS, L. -G. Nilsson, PhD, M. Cruts, PhD, R. Adolfsson, MD PhD, C. Van Broeckhoven, PhD and L. Nyberg, PhD

From the Departments of Psychology (Dr. Nyberg, A. Sundström and P. Marklund) and Clinical Sciences and Psychiatry (Dr. Adolfsson), Umeå University, and Department of Psychology (Dr. Nilsson), Stockholm University, Sweden; and Department of Molecular Genetics (Drs. Cruts and Van Broeckhoven), Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium.

Address correspondence and reprint requests to A. Sundström, Department of Psychology, Umeå University, S-901 87 Umeå, Sweden; e-mail: anna.sundstrom{at}psy.umu.se

Objective: To examine the relationship between neuropsychological outcome following mild head injury (MHI) and APOE genotype.

Methods: Data from a population-based longitudinal study (n = 3,500) were used to identify 34 adults who experienced MHI during the course of the study. Their pre- and postinjury performances on a battery of nine neuropsychological tests were compared within person, and the postinjury performance was compared with that of age- and gender-matched control subjects.

Results: The within-person comparisons showed that participants with at least one APOE {epsilon}4 allele (n = 11) had a significantly decreased postinjury performance on three of the tests, whereas the postinjury performance for APOE {epsilon}4-negative participants (n = 23) was unchanged. There was no significant difference in postinjury performance between participants with/without the {epsilon}4 allele, and neither group was impaired relative to controls.

Conclusions: APOE genotype may influence the outcome following an MHI. Pre/postinjury within-person comparisons seem more sensitive than control group comparisons for detecting injury-related effects.

Received July 28, 2003. Accepted in final form December 16, 2003.




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Correspondence:

Read all Correspondence

APOE influences on neuropsychological function after mild head injury: Within-person comparisons
Alexander Collie, PhD, et al.
Neurology Online, 6 Jul 2004 [Full text]
Reply to Collie et al
Anna Sundström, et al.
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