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NEUROLOGY 2004;62:2092-2094
© 2004 American Academy of Neurology
Brief Communications

Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects

V. Lampasona, BSc, D. Franciotta, MD, R. Furlan, MD, S. Zanaboni, BSc, R. Fazio, MD, E. Bonifacio, PhD, G. Comi, MD and G. Martino, MD

From the Department of Clinical Chemistry (Dr. Bonifacio, V. Lampasona and S. Zanaboni), Neuroimmunology Unit, DIBIT, Department of Neuroscience (Drs. Furlan and Martino), and Department of Neurology and Neurophysiology (Drs. Fazio, Comi, and Martino), University Vita-Salute, San Raffaele Scientific Institute, Milan, Italy; and Laboratory of Neuroimmunology (Dr. Franciotta), IRCCS "C. Mondino" Neurological Institute, University of Pavia, Italy.

Address correspondence and reprint requests to Dr. Martino, Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, via Olgettina 48, 20132 Milan, Italy; e-mail: martino.gianvito{at}hsr.it

The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis (MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects. Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects. The frequency of positive samples with low titers of anti-MOG IgG (≤5.7%) and IgM (≤8.3%) was similar in all the groups and subgroups. Binding competition experiments showed that these antibodies had low affinity. Anti-MOG antibodies are not disease specific.

Received November 3, 2003. Accepted in final form February 2, 2004.

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