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NEUROLOGY 2004;62:2101-2102
© 2004 American Academy of Neurology
Brief Communications

Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies

R. Nemni, MD, L. M. Caniatti, MD, M. Gironi, MD, E. Bazzigaluppi, BD and D. De Grandis, MD

From the Department of Neurological Rehabilitation (Drs. Nemni and Gironi), Don C. Gnocchi Foundation, University of Milan, Italy; Department of Neurology (Dr. Caniatti), S. Anna Hospital, University of Ferrara, Italy; Diagnostic Laboratory (E. Bazzigaluppi), San Raffaele Scientific Institute, Milan, Italy; and Department of Neurology (Dr. De Grandis), Rovigo Civic Hospital, Italy.

Address correspondence and reprint requests to Dr. Raffaello Nemni, Department of Neurological Rehabilitation, Don C. Gnocchi Foundation, University of Milan, 20148 Milan, Italy; e-mail: raffaello.nemni{at}unimi.it

The authors report the presence of high titer antibodies to glutamic acid decarboxylase (anti-GAD65) until age 24 months in two asymptomatic newborns of a woman with stiff-person syndrome (SPS). No signs of SPS were detectable in the two children at ages 6 and 8 years. This observation indicates that other cofactors are involved in the pathogenesis of SPS.

Received November 17, 2003. Accepted in final form February 3, 2004.




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T. M. Burns, L. H. Phillips II, H. R. Jones, R. Nemni, L.M. Caniatti, M. Gironi, E. Bazzigaluppi, and D. D. Grandis
Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies
Neurology, January 25, 2005; 64(2): 399 - 400.
[Full Text] [PDF]

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Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies
Ted M. Burns, et al.
Neurology Online, 26 Jul 2004 [Full text]
Reply to Burns et al
Raffaello Nemni, et al.
Neurology Online, 26 Jul 2004 [Full text]

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