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NEUROLOGY 2004;62:2110-2112
© 2004 American Academy of Neurology
Brief Communications

The effect of combined thrombolysis with rtPA and tirofiban on ischemic brain lesions

R. J. Seitz, MD, S. Meisel, MD, M. Moll, MD, H. -J. Wittsack, PhD, U. Junghans, MD and M. Siebler, MD

From the Department of Neurology (Drs. Seitz, Meisel, Moll, Junghans, and Siebler), Institute of Diagnostic Radiology (Dr. Wittsack), Heinrich-Heine University of Düsseldorf, Germany.

Address correspondence and reprint requests to Dr. Rüdiger J. Seitz, Department of Neurology, University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany; e-mail: seitz{at}neurologie.uni-duesseldorf.de

To determine the effect of systemic thrombolysis with low-dose recombinant tissue plasminogen activator (rtPA) and the body-weight adjusted platelet GPIIb/IIIa receptor antagonist tirofiban, the authors performed lesion volumetry on magnetic resonance perfusion and diffusion images recorded before thrombolysis and on T2-weighted magnetic resonance images on day 8. Treatment with rtPA and tirofiban (n = 13) resulted in a 50% lesion reduction (p < 0.03), while lesion reduction was less in rtPA treatment (n = 16) and absent in nontreated patients (n = 18).

Received July 28, 2003. Accepted in final form January 29, 2004.




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