Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Plewnia, C.
Right arrow Articles by Gerloff, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Plewnia, C.
Right arrow Articles by Gerloff, C.
Related Collections
Right arrow All Clinical trials
Right arrow Clinical trials Observational study (Cohort, Case control)
Right arrow Plasticity
NEUROLOGY 2004;62:2124-2126
© 2004 American Academy of Neurology
Brief Communications

Improved motor skill acquisition after selective stimulation of central norepinephrine

Christian Plewnia, MD, Julia Hoppe, Leonardo G. Cohen, MD and Christian Gerloff, MD

From the Cortical Physiology Research Group, Department of General Neurology, Hertie Institute for Clinical Brain Research (Drs. Plewnia and Gerloff, J. Hoppe), and Neurophysiology Section, Department of Psychiatry (Dr. Plewnia), University of Tuebingen, Germany; and Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke (Dr. Cohen), NIH Bethesda, MD.

Address correspondence and reprint requests to Dr. C. Gerloff, Cortical Physiology Research Group, Department of Neurology, Eberhard-Karls University Medical School, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany; e-mail: christian.gerloff{at}uni-tuebingen.de

It has been proposed that the beneficial effects of training on motor function can be enhanced by stimulation of {alpha}-adrenergic mechanisms. Consistent with this view, a single oral dose of the selective norepinephrine reuptake inhibitor reboxetine was found to enhance motor skill acquisition (rapid elbow flexion) and corticomotor excitability tested with transcranial magnetic stimulation in the absence of effects on basal motor performance. Therefore, {alpha}-adrenergic mechanisms could possibly be manipulated to magnify training effects in neurorehabilitation.

Received December 14, 2003. Accepted in final form January 31, 2004.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
C. Grefkes, L. E. Wang, S. B. Eickhoff, and G. R. Fink
Noradrenergic Modulation of Cortical Networks Engaged in Visuomotor Processing
Cereb Cortex, August 17, 2009; (2009) bhp144v1.
[Abstract] [Full Text] [PDF]

Home page
 Neurorehabil Neural RepairHome page
S. Zittel, C. Weiller, and J. Liepert
Citalopram Improves Dexterity in Chronic Stroke Patients
Neurorehabil Neural Repair, June 1, 2008; 22(3): 311 - 314.
[Abstract] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Solis and D. J. Perkel
Noradrenergic Modulation of Activity in a Vocal Control Nucleus In Vitro
J Neurophysiol, April 1, 2006; 95(4): 2265 - 2276.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Gerloff, K. Bushara, A. Sailer, E. M. Wassermann, R. Chen, T. Matsuoka, D. Waldvogel, G. F. Wittenberg, K. Ishii, L. G. Cohen, et al.
Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke
Brain, March 1, 2006; 129(3): 791 - 808.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
B. H. Dobkin
Rehabilitation after Stroke
N. Engl. J. Med., April 21, 2005; 352(16): 1677 - 1684.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by AAN Enterprises, Inc.