HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Video Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bowyer, S. M. Articles by Tepley, N. Search for Related Content PubMed PubMed Citation Articles by Bowyer, S. M. Articles by Tepley, N. Related Collections All Neuropsychology/Behavior Aphasia Neuropsychological assessment All Epilepsy/Seizures WADA test Cortical localization Functional neuroimaging

MEG localization of language-specific cortex utilizing MR-FOCUSS

From the Department of Neurology (Drs. Bowyer, Moran, Constantinou, Smith, Barkley, and Tepley, K.M. Mason), Henry Ford Health System, Neuromagnetism Lab, Detroit, MI; Department of Physics (Drs. Bowyer and Tepley), Oakland University, Rochester, MI; and Department of Neurology (Drs. Bowyer and Smith), Wayne State University, Detroit, MI.

Address correspondence and reprint requests to Dr. S.M. Bowyer, Henry Ford Hospital, Neuromagnetism Lab, CFP 78/79, 2799 West Grand Boulevard, Detroit, MI 48202; e-mail: drsusan{at}umich.ed

Objective: To demonstrate noninvasive localization of cognitive cortical areas involved in language processing with magnetoencephalography (MEG) interpreted by multiresolution FOCUSS (MR-FOCUSS), a current density imaging technique.

Method: MEG data were collected during verb-generation and picture-naming tasks from 18 right-handed control subjects and 24 right-handed patients with epilepsy.

Results: The averaged epic data from the verb-generation task, analyzed by MR-FOCUSS, showed initial activation in the left supramarginal gyrus, superior temporal gyrus, and angular gyrus at 239 ± 31 ms in all subjects, consistent with other language mapping studies. Average amplitude of underlying cortical sources was 452 pAm. The averaged epic data from the picture-naming task, analyzed by MR-FOCUSS, showed activation in the left inferior frontal gyrus (IFG) area starting at 436 ± 40 ms in all subjects. Average amplitudes of underlying cortical sources were 380 pAm.

Conclusion: The time course of neuronal language processing can be imaged noninvasively with millisecond resolution by magnetoencephalography using the multiresolution FOCUSS technique.

Received May 29, 2003. Accepted in final form February 18, 2004.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 22 issue to find the title link for this article.

This article has been cited by other articles:

				A. C. Papanicolaou, P. G. Simos, E. M. Castillo, S.M. Bowyer, J.E. Moran, K.M. Mason, J.E. Constantinou, B.J. Smith, G.L. Barkley, and N. Tepley MEG localization of language-specific cortex utilizing MR-FOCUSS Neurology, February 22, 2005; 64(4): 765 - 765. [Full Text] [PDF]

Correspondence: