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NEUROLOGY 2004;62:2288-2290
© 2004 American Academy of Neurology
Brief Communications

Thalidomide neurotoxicity

Prospective study in patients with lupus erythematosus

C. Briani, MD, G. Zara, MD, R. Rondinone, MD, S. Della Libera, MD, M. Ermani, MD, S. Ruggero, PhD, A. Ghirardello, PhD, S. Zampieri, PhD and A. Doria, MD

From the Department of Neurosciences (Drs. Briani, Zara, Ermani, and Ruggero), Department of Medical and Surgical Sciences (Drs. Rondinone, Della Libera, Ghirardello, Zampieri, and Doria), Rheumatology Division, University of Padova, Italy.

Address correspondence and reprint requests to Dr. Chiara Briani, Department of Neurosciences, University of Padova, Via Giustiniani, 5, 35128 Padova, Italy; e-mail: chiara.briani{at}unipd.it

The authors prospectively followed 14 patients treated with thalidomide for cutaneous lupus erythematosus (CLE), in order to evaluate the occurrence of peripheral neuropathy (PN) and to assess whether PN correlates with thalidomide dose. The patients were followed for up to 24 months with neurologic and electrophysiologic evaluations. Seven patients (50%) developed sensory axonal PN. The median time free from PN was 14 months. PN occurred after 10 months in the majority of patients. No correlations were found between thalidomide cumulative dose and occurrence of PN (Mann-Whitney U test; p > 0.16).

Received December 17, 2003. Accepted in final form February 17, 2004.

See also pages 2158 and 2291




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