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NEUROLOGY 2004;62:2291-2293
© 2004 American Academy of Neurology
Brief Communications

Thalidomide sensory neurotoxicity

A clinical and neurophysiologic study

G. Cavaletti, MD, A. Beronio, MD, L. Reni, MD, E. Ghiglione, MD, A. Schenone, MD, C. Briani, MD, G. Zara, MD, D. Cocito, MD, G. Isoardo, MD, P. Ciaramitaro, MD, R. Plasmati, MD, F. Pastorelli, MD, M. Frigo, MD, M. Piatti, MD and M. Carpo, MD PhD

From the Dipartimento di Neuroscienze e Tecnologie Biomediche (Drs. Cavaletti and Piatti), Università di Milano Bicocca, Monza, Dipartimento di Neuroscienze, Oftalmologia e Genetica and Centro di Eccellenza per la Ricerca Biomedica (Drs. Beronio, Reni, Ghiglione, and Schenone), Università di Genova, Dipartimento di Neuroscienze (Drs. Briani and Zara), Università di Padova, U.O. Neurofisiologia Clinica–S.C. Neurologia I D.U. (Drs. Cocito, Isoardi, and Ciaramitaro), Dipartimento di Neuroscienze, Università di Torino, Dipartimento di Scienze Neurologiche (Drs. Plasmati and Pastorelli), Unità Operativa di Neurologia, Ospedale Bellaria Bologna, Clinica Neurologica (Dr. Frigo), A.O. S. Gerardo, Monza, and Dipartimento di Scienze Neurologiche (Dr. Carpo), Università di Milano, IRCCS Ospedale Maggiore Policlinico, Italia.

Address correspondence and reprint requests to Dr. G. Cavaletti, Clinica Neurologica, Ospedale S. Gerardo, v. Donizetti 106, 20052 Monza (MI), Italia; e-mail: guido.cavaletti{at}unimib.it

The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.

Received December 18, 2003. Accepted in final form March 8, 2004.

See also pages 2158 and 2288




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