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Diet therapy for narcolepsy

From the Divisions of Neurology (Dr. Husain) and General Internal Medicine (Drs. Yancy and Westman), Department of Medicine, Duke University Medical Center, and Neurodiagnostic Center (Dr. Husain, S.T. Carwile and P.P. Miller) and Center for Health Services Research in Primary Care (Dr. Yancy), Department of Veterans Affairs Medical Center, Durham, NC.

Address correspondence and reprint requests to Dr. A.M. Husain, Duke University Medical Center, 202 Bell Bldg., Box 3678, Durham, NC 27710; e-mail: Aatif.husain{at}duke.edu

The effects of a low-carbohydrate, ketogenic diet (LCKD) on sleepiness and other narcolepsy symptoms were studied. Nine patients with narcolepsy were asked to adhere to the Atkins’ diet plan, and their symptoms were assessed using the Narcolepsy Symptom Status Questionnaire (NSSQ). The NSSQ–Total score decreased by 18% from 161.9 to 133.5 (p = 0.0019) over 8 weeks. Patients with narcolepsy experienced modest improvements in daytime sleepiness on an LCKD.

Received October 3, 2003. Accepted in final form February 23, 2004.

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