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NEUROLOGY 2004;62:2326-2327
© 2004 American Academy of Neurology
Brief Communications

Multiple sclerosis and occult gluten sensitivity

Connie D.S.N.A. Pengiran Tengah, MRCP, Robert J. Lock, MPhil, D. Joseph Unsworth, PhD and Adrian J. Wills, MD

From the Department of Neurology (Drs. Pengiran Tengah and Wills), Derbyshire Royal Infirmary, Derby, Department of Immunology and Immunogenetics (Dr. Unsworth, R.J. Lock), Southmead Hospital, Bristol, and Department of Neurology (Dr. Wills), University Hospital, Queen’s Medical Centre, Nottingham, UK.

Address correspondence and reprint requests to Dr. A.J. Wills, Department of Neurology, University Hospital, Queen’s Medical Centre, Nottingham, NG7 2 UH, UK; e-mail: adewills61{at}hotmail.com

Two atypical patients with a multiple sclerosis (MS)–like illness and evidence of occult celiac disease (CD) were managed by the authors. This prompted screening of a further 49 unselected MS cases for serologic evidence of CD. IgA anti-endomysial antibody was found in one case (2%). IgG anti-gliadin antibody was found in 12% of patients and 13% of blood donors. Anti-gliadin antibody (especially IgG isotype) can be a nonspecific finding.

Received November 25, 2003. Accepted in final form February 3, 2004.




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M. Hadjivassiliou, D. S. Sanders, R. A. Grunewald, A. J. Wills, D. J. Unsworth, R. J. Lock, and C. D.S.N.A. Pengiran Tengah
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Correspondence:

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Multiple sclerosis and occult gluten sensitivity
Marios Hadjivassiliou, et al.
Neurology Online, 27 Oct 2004 [Full text]
Reply to Hadjivassiliou et al
Adrian J Wills, et al.
Neurology Online, 27 Oct 2004 [Full text]

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