HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koller, W. C. Articles by Tse, W. Search for Related Content PubMed PubMed Citation Articles by Koller, W. C. Articles by Tse, W.

Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

Unmet medical needs in Parkinson’s disease

From the Department of Neurology, Mt. Sinai School of Medicine, New York, NY.

Address correspondence and reprint requests to Dr. William Koller, Department of Neurology, Mt. Sinai School of Medicine, 1 Gustave Levy Place, Annenberg 1494, New York, NY 10029.

Levodopa, introduced in the late 1960s, was the first highly effective drug for the symptomatic treatment of Parkinson’s disease (PD) and remains the mainstay of pharmacologic treatment. However, long-term treatment has important limitations. The disease continues to progress despite treatment with levodopa, and a neuroprotective therapy is urgently required. In addition, motor complications associated with chronic levodopa therapy are an important source of disability. Treatment of these complications forms a major focus of modern PD management, and it is in this area that recent advances in our knowledge offer the best opportunity for therapeutic gain. In the search for improved therapies, suitable outcome measures to better assess overall disability in PD and disease progression are essential.

This article has been cited by other articles:

				M. S. Weinberg and M. J.A. Wood Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics Hum. Mol. Genet., April 15, 2009; 18(R1): R27 - R39. [Abstract] [Full Text] [PDF]

				W. Simonson, R. A Hauser, and A. H. Schapira Role of the Pharmacist in the Effective Management of Wearing-Off in Parkinson's Disease Ann. Pharmacother., November 1, 2007; 41(11): 1842 - 1849. [Abstract] [Full Text] [PDF]

Correspondence: