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Valproic acid has no effect on pain in polyneuropathy

A randomized, controlled trial

From the Department of Neurology (Drs. Otto and Sindrup), Odense University Hospital, Denmark; and Dansk Pain Research Center (Drs. Bach and Jensen), Aarhus University Hospital, Denmark.

Address correspondence and reprint requests to Marit Otto, Department of Neurology, Odense University Hospital, DK-5000 Odense, Denmark; e-mail: maritotto{at}dadlnet.dk

The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks’ duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings.

Received June 23, 2003. Accepted in final form September 24, 2003.

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