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From the Departments of Neurology (Drs. Pennell, Helmers, and Henry, J.Q. Montgomery), Psychiatry and Behavioral Sciences (Drs. Newport and Stowe), and Gynecology and Obstetrics (Dr. Stowe), Emory University School of Medicine, Atlanta, GA.
Address correspondence and reprint requests to Dr. P.B. Pennell, Department of Neurology, WMB 6000, Emory University School of Medicine, Atlanta, GA 30322; e-mail: page_pennell{at}emoryhealthcare.org
This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks’ gestational age, reaching a peak of >330% of baseline, and then began to decline.
Received July 1, 2003. Accepted in final form September 17, 2003.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 27 issue to find the title link for this article.
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