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Reversible language regression as an adverse effect of topiramate treatment in children

From the Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.

Address correspondence and reprint requests to Dr. R.S. Shalev, Neuropediatric Unit, Shaare Zedek Medical Center, Post Office Box 3235, Jerusalem 91031, Israel; e-mail: shalev{at}szmc.org.il

Profound language regression developed in three children with epilepsy 4 to 28 weeks after beginning topiramate (TPM). TPM was administered as an adjunctive antiepileptic drug at doses of 2.5 to 6.0 mg/kg/day. Language functions recovered while TPM was being reduced in dose or stopped.

Received July 25, 2003. Accepted in final form September 19, 2003.

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