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NEUROLOGY 2004;62:301-303
© 2004 American Academy of Neurology


Brief Communications

Low androgenization index in elderly women and elderly men with Alzheimer’s disease

A. M. Paoletti, MD, S. Congia, MD, S. Lello, MD, D. Tedde, MD, M. Orrù, PhD, M. Pistis, MD, M. Pilloni, MD, P. Zedda, Midwife, A. Loddo, MD and G. B. Melis, MD

From the Departments of Obstetrics and Gynecology (Drs. Paoletti, Lello, Orrù, Pistis, Pilloni, Loddo, Melis, and P. Zedda) and Neurology (Drs. Congia and Tedde), University of Cagliari, Italy.

Address correspondence and reprint requests to Prof. Gian Benedetto Melis, Chairman, Department of Obstetrics and Gynecology, University of Cagliari, Ospedale San Giovanni di Dio, Via Ospedale 46, I-09124 Cagliari, Italy; e-mail: paoletti{at}freemail.it

The authors investigated whether testosterone levels and testosterone availability differ between older lean subjects with and without Alzheimer’s disease (AD). Sex hormone binding globulin (SHBG) and estradiol levels were higher, whereas the free androgenization index (FAI) was lower, in lean subjects with AD than in lean subjects without AD. Factors involved in the increase of SHBG secretion could have an important role in the lower testosterone availability of subjects with AD.


Received January 22, 2003. Accepted in final form July 29, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 27 issue to find the title link for this article.




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