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NEUROLOGY 2004;62:313-315
© 2004 American Academy of Neurology
Brief Communications

Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD

E. Golanska, PhD, K. Hulas–Bigoszewska, MS, E. Rutkiewicz, MS, M. Styczynska, MD, B. Peplonska, MS, M. Barcikowska, MD, J. Bratosiewicz–Wasik, PhD and P. P. Liberski, MD

From the Department of Molecular Pathology and Neuropathology (Drs. Golanska and Liberski, K. Hulas–Bigoszewska and E. Rutkiewicz), Medical University of Lodz, Department of Neurodegenerative Disorders (Drs. Styczynska and Barcikowska, B. Peplonska), Medical Research Center, Polish Academy of Sciences, Warsaw, and Department of Virological Diagnostics (Dr. Bratosiewicz–Wasik), Medical University of Silesia, Katowice, Poland.

Address correspondence and reprint requests to Dr. E. Golanska, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, 8/10 Czechoslowacka str., 92-216 Lodz, Poland; e-mail: golanska{at}wp.pl

The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer’s disease (AD). DNA from 79 Polish patients with probable AD and 107 healthy control subjects was studied. The PRNP codon 129 homozygosity seemed to be associated with the occurrence of AD: In AD patients, the percentage of Val/Val and Met/Met genotypes was higher than in the control subjects. A significant difference appeared also between early-onset (<70 years) and late-onset (>=70 years) AD patients in the PRND genotypes.

Received April 9, 2003. Accepted in final form September 24, 2003.




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[Abstract] [Full Text] [PDF]

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Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD
Katell Peoc'h, et al.
Neurology Online, 28 Jun 2004 [Full text]

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