HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Golanska, E. Articles by Liberski, P. P. Search for Related Content PubMed PubMed Citation Articles by Golanska, E. Articles by Liberski, P. P.

Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD

From the Department of Molecular Pathology and Neuropathology (Drs. Golanska and Liberski, K. Hulas–Bigoszewska and E. Rutkiewicz), Medical University of Lodz, Department of Neurodegenerative Disorders (Drs. Styczynska and Barcikowska, B. Peplonska), Medical Research Center, Polish Academy of Sciences, Warsaw, and Department of Virological Diagnostics (Dr. Bratosiewicz–Wasik), Medical University of Silesia, Katowice, Poland.

Address correspondence and reprint requests to Dr. E. Golanska, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, 8/10 Czechoslowacka str., 92-216 Lodz, Poland; e-mail: golanska{at}wp.pl

The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer’s disease (AD). DNA from 79 Polish patients with probable AD and 107 healthy control subjects was studied. The PRNP codon 129 homozygosity seemed to be associated with the occurrence of AD: In AD patients, the percentage of Val/Val and Met/Met genotypes was higher than in the control subjects. A significant difference appeared also between early-onset (<70 years) and late-onset (70 years) AD patients in the PRND genotypes.

Received April 9, 2003. Accepted in final form September 24, 2003.

This article has been cited by other articles:

				O. Stuve, C. Korth, P. Gabatto, E. M. Cameron, W. Hu, T. N. Eagar, N. L. Monson, E. M. Frohman, M. K. Racke, C. P. Zabetian, et al. Genetic Polymorphism at Codon 129 of the Prion Protein Gene Is Not Associated With Multiple Sclerosis Arch Neurol, February 1, 2009; 66(2): 280 - 281. [Full Text] [PDF]

				R. Linden, V. R. Martins, M. A. M. Prado, M. Cammarota, I. Izquierdo, and R. R. Brentani Physiology of the Prion Protein Physiol Rev, April 1, 2008; 88(2): 673 - 728. [Abstract] [Full Text] [PDF]

Correspondence: