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NEUROLOGY 2004;62:319-322
© 2004 American Academy of Neurology
Brief Communications

Widespread increased expression of the DNA repair enzyme PARP in brain in ALS

S. H. Kim, MD PhD, J. I. Engelhardt, MD PhD, J. S. Henkel, PhD, L. Siklós, PhD, J. Soós, MD, C. Goodman, MD and S. H. Appel, MD

From the Departments of Neurology (Drs. Kim, Henkel, Goodman, and Appel) and Pathology (Dr. Goodman), Baylor College of Medicine, Houston, TX; Department of Neurology (Dr. Kim), Hanyang University Hospital, Seoul, Korea; and Department of Neurology (Drs. Engelhardt and Soós), University of Szeged, and Department of Biophysics (Dr. Siklós), Biological Research Center, Szeged, Hungary.

Address correspondence and reprint requests to Dr. S.H. Appel, Department of Neurology, Baylor College of Medicine, 6501 Fannin, NB302, Houston, TX 77030; e-mail: sappel{at}bcm.tmc.edu

Expression of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) is a known response to oxidative damage of DNA. In ALS brain, PARP expression by western analyses was increased in the motor cortex, parietal cortex, and cerebellum. PARP immunostaining in the motor cortex was increased in ALS neurons and subcortical glia and macrophages. Importantly, there was widespread increased PARP expression in neurons in the parietal cortex and cerebellum, regions that are typically clinically unaffected in ALS, suggesting widespread oxidative stress.

Received April 9, 2003. Accepted in final form September 17, 2003.




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