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NEUROLOGY 2004;62:323-326
© 2004 American Academy of Neurology
Brief Communications

Multiparametric MRI in a patient with adult-onset leukoencephalopathy with vanishing white matter

A. Gallo, MD, M. A. Rocca, MD, A. Falini, MD, C. Scaglione, MD, F. Salvi, MD, A. Gambini, MD, L. Guerrini, MD, M. Mascalchi, MD PhD, J. C. Pronk, PhD, M. S. van der Knaap, MD PhD and M. Filippi, MD

From the Neuroimaging Research Unit, Department of Neurology (Drs. Gallo, Rocca, and Filippi) and Neuroradiology (Drs. Falini and Gambini), Scientific Institute and University Ospedale San Raffaele, Milan; Department of Clinical Neurology (Drs. Scaglione and Salvi), Ospedale Bellaria, University of Bologna; Radiodiagnostic Section (Drs. Guerrini and Mascalchi), Department of Clinical Physiopathology, University of Florence, Italy; and Departments of Clinical and Human Genetics (Dr. Pronk) and Child Neurology (Dr. van der Knaap), Free University Medical Center, Amsterdam, the Netherlands.

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy; e-mail: massimo.filippi{at}hsr.it

This is a multiparametric MR study of the first reported patient with adult-onset genetically confirmed vanishing white matter (VWM) disease. It shows that, despite the presence of a severe and diffuse damage of the brain WM, brain gray matter, and cervical cord tissue, the cortical adaptive capacities were relatively preserved. Interpatient variability of brain plasticity may contribute to the known phenotypic variation of patients with VWM disease.

Received July 17, 2003. Accepted in final form September 23, 2003.




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