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The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD

Address correspondence and reprint requests to Dr. S.R. Schwid, Department of Neurology, University of Rochester Medical Center, 601 Elmwood Ave., Box 605, Rochester, NY 14642; e-mail: steven_schwid{at}urmc.rochester.edu

CEP-1347 is an inhibitor of members of the mixed lineage kinase family, key signals triggering apoptotic neuronal death. The authors performed a randomized, blinded, placebo-controlled study assessing the safety, tolerability, pharmacokinetics, and acute symptomatic effects of CEP-1347 in 30 patients with Parkinson’s disease (PD). In this short-term study, CEP-1347 was safe and well tolerated. It had no acute effect on parkinsonian symptoms or levodopa pharmacokinetics, making it well suited for larger and longer studies of its potential to modify the course of PD.

Received May 28, 2003. Accepted in final form October 10, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 27 issue to find the title link for this article.

*See the Appendix on page 332 for a list of contributing members.

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