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Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia

From the Centre d’étude du sommeil et des rythmes biologiques (J.-F. Gagnon and S. Rompré, and Drs. Fantini, Petit, Carrier, Décary, and Montplaisir), Hôpital du Sacré-Cur de Montréal; Unité des troubles du mouvement André Barbeau (J.-F. Gagnon and Dr. Bédard), Centre Hospitalier de l’Université de Montréal; and McGill Center for Studies in Aging (Dr. Panisset), Douglas Hospital and McGill University of Montreal, Canada.

Address correspondence and reprint requests to Dr. Jacques Montplaisir, Centre d’étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Cur de Montréal, 5400, boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5; e-mail: j-montplaisir{at}crhsc.umontreal.ca

Objective: To compare nondemented patients with Parkinson’s disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep.

Methods: Fifteen patients with PD (7 patients with polysomnographic-confirmed RBD [PD-RBD] and 8 patients without RBD [PD-NRBD]) and 15 healthy control subjects were studied. Each subject underwent a quantitative EEG analysis of both wakefulness and REM sleep.

Results: During wakefulness, patients with PD-RBD showed a higher theta power in frontal, parietal, temporal, and occipital regions in comparison to patients with PD-NRBD and control subjects. Moreover, a slowing of the dominant occipital frequency was observed only in patients with PD-RBD (p < 0.02). Patients with PD-NRBD did not present any slowing of the EEG. No between-group difference in quantitative REM sleep EEG was observed.

Conclusions: This study demonstrates that the EEG slowing reported during wakefulness in nondemented patients with PD is strongly related to the presence of RBD.

Received March 18, 2003. Accepted in final form September 17, 2003.

Presented in part as a poster at the annual meeting of the American Academy of Neurology; Hawaii; March–April, 2003.

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