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NEUROLOGY 2004;62:476-478
© 2004 American Academy of Neurology
Brief Communications

Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica

M. A. Rocca, MD, F. Agosta, MD, D. M. Mezzapesa, MD, V. Martinelli, MD, F. Salvi, MD, A. Ghezzi, MD, R. Bergamaschi, MD, G. Comi, MD and M. Filippi, MD

From the Neuroimaging Research Unit (Drs. Rocca, Agosta, Mezzapesa, and Filippi), Department of Neurology (Drs. Rocca, Agosta, Mezzapesa, Martinelli, Comi, and Filippi), Scientific Institute and University Ospedale San Raffaele, Milan; Department of Clinical Neurology (Dr. Salvi), Ospedale Bellaria, University of Bologna; Multiple Sclerosis Center (Dr. Ghezzi), Ospedale di Gallarate; and Department of Neurology (Dr. Bergamaschi), Istituto Mondino, Pavia, Italy.

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy; e-mail: m.filippi{at}hsr.it

Using magnetization transfer (MT) and diffusion tensor (DT) MRI, the authors assessed the extent of tissue damage of the brain normal-appearing white and gray matter (NAGM) in patients with neuromyelitis optica (NMO). Compared to healthy controls, patients with NMO showed reduced MT ratio and increased mean diffusivity of the NAGM. This challenges the classic notion of a sparing of the brain tissue in the course of NMO.

Received July 17, 2003. Accepted in final form October 6, 2003.




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