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NEUROLOGY 2004;62:486-488
© 2004 American Academy of Neurology
Brief Communications

Second-line anticonvulsant treatment of neonatal seizures

A video-EEG monitoring study

G. B. Boylan, PhD, J. M. Rennie, MD, G. Chorley, R. M. Pressler, MD, G. F. Fox, MB, K. Farrer, MB, M. Morton, MB and C. D. Binnie, MD

From the Departments of Child Health (Drs. Boylan, Rennie, Fox, Farrer, and Morton, G. Chorley) and Neurophysiology (Drs. Pressler and Binnie), Guy’s King’s St Thomas’ School of Medicine, London, UK.

Address correspondence and reprint requests to Dr. G.B. Boylan, Department of Paediatrics and Child Health, Clinical Investigations Unit, Cork University Hospital, Wilton, Cork, Ireland; e-mail: g.boylan{at}ucc.ie

The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.

Received February 14, 2003. Accepted in final form September 18, 2003.




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