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Defective auditory interhemispheric transfer in a patient with a PAX6 mutation

From the Neuro-otology Department (Drs. Bamiou and Davies), National Hospital for Neurology and Neurosurgery, London, UK; Communication Sciences (Dr. Musiek), DCP Communications Center, University of Connecticut, Storrs, CT; and Department of Clinical and Experimental Epilepsy (Drs. Sisodiya and Free, T.N. Mitchell), UCL Institute of Neurology, London, UK.

Address correspondence and reprint requests to Dr. Doris-Eva Bamiou, Neuro-otology Department, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; e-mail: Doris-Eva.Bamiou{at}uclh.org

Heterozygous PAX6 mutation is associated with an absent or hypoplastic anterior commissure and a reduction in the area of the corpus callosum. The authors found deficient auditory interhemispheric transfer in a 53-year-old woman with a PAX6 mutation who had an absent anterior commissure but normal callosal volume.

Received July 15, 2003. Accepted in final form October 6, 2003.

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