Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jin, K.
Right arrow Articles by Itoyama, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jin, K.
Right arrow Articles by Itoyama, Y.
Related Collections
Right arrow Prion
Right arrow All Genetics
NEUROLOGY 2004;62:502-505
© 2004 American Academy of Neurology
Brief Communications

Clinical features of Creutzfeldt-Jakob disease with V180I mutation

K. Jin, MD, Y. Shiga, MD PhD, S. Shibuya, MD PhD, K. Chida, MD PhD, Y. Sato, MD PhD, H. Konno, MD PhD, K. Doh-ura, MD PhD, T. Kitamoto, MD PhD and Y. Itoyama, MD PhD

From the Department of Neurology (Drs. Jin, Shiga, and Itoyama), Tohoku University School of Medicine, Sendai, Department of Neurology (Dr. Shibuya), Miyagi National Hospital, Yamamoto, Department of Neurology (Dr. Chida), Kohnan Hospital, Sendai, Department of Neurology (Dr. Sato), Research Institute for Brain and Blood Vessels-Akita, Akita, Department of Neurology (Dr. Konno), Nishitaga National Hospital, Sendai, Department of Neuropathology (Dr. Koh-ura), Neurological Institute, Kyushu University Faculty of Medicine, Fukuoka, and Department of Neurological Science (Dr. Kitamoto), Tohoku University School of Medicine, Sendai, Japan.

Address correspondence and reprint requests to Dr. Y. Shiga, Department of Neurology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; e-mail: yshiga{at}em.neurol.med.tohoku.ac.jp

The authors describe the clinical features of Creutzfeldt-Jakob disease (CJD) with the causative point mutation at codon 180. The symptoms never started with visual or cerebellar involvement. The patients showed slower progression of the disease compared with sporadic CJD. They never showed periodic sharp and wave complexes in EEG. MRI demonstrated remarkable high-intensity areas with swelling in the cerebral cortex except for the medial occipital and cerebellar cortices. These characteristic MRI findings are an important clue for an accurate premortem diagnosis.

Received April 16, 2003. Accepted in final form October 6, 2003.

Presented in part at the 127th annual meeting of the American Neurological Association, New York, NY, October 14, 2002.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
G. S. Young, M. D. Geschwind, N. J. Fischbein, J. L. Martindale, R. G. Henry, S. Liu, Y. Lu, S. Wong, H. Liu, B. L. Miller, et al.
Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis
AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1551 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. Shiga, K. Miyazawa, S. Sato, R. Fukushima, S. Shibuya, Y. Sato, H. Konno, K. Doh-ura, S. Mugikura, H. Tamura, et al.
Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease
Neurology, August 10, 2004; 63(3): 443 - 449.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by AAN Enterprises, Inc.