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NEUROLOGY 2004;62:644-647
© 2004 American Academy of Neurology
Brief Communications

Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas

A. Schulze-Bonhage, MD, V. Homberg, MD, M. Trippel, MD, R. Keimer, MD, C. E. Elger, MD, P. C. Warnke, MD and C. Ostertag, MD

From the Epilepsy Center (Drs. Schulze-Bonhage and Homberg), Department of Stereotactic Neurosurgery (Drs. Trippel, Warnke, and Ostertag), University Clinics of Freiburg; Department of Neuropediatrics (Dr. Keimer), Olgahospital Stuttgart; and Clinic for Epileptology (Dr. Elger), University Clinic of Bonn, Germany.

Address correspondence and reprint requests to Dr. A. Schulze-Bonhage, Epilepsy Centre, University Clinics of Freiburg, Breisacher Str. 64, D-79106 Freiburg, FRG; e-mail: schulzeb{at}nz.ukl.uni-freiburg.de

The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients had become seizure-free within 2 months, and two others had only persisting auras. There were no major perioperative or postoperative side effects.

Received May 23, 2003. Accepted in final form October 6, 2003.




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A. Schulze-Bonhage, M. Trippel, K. Wagner, T. Bast, F. V. Deimling, A. Ebner, C. Elger, T. Mayer, R. Keimer, B. J. Steinhoff, et al.
Outcome and predictors of interstitial radiosurgery in the treatment of gelastic epilepsy
Neurology, July 22, 2008; 71(4): 277 - 282.
[Abstract] [Full Text] [PDF]


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