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NEUROLOGY 2004;62:654-656
© 2004 American Academy of Neurology
Brief Communications

CSF soluble Fas correlates with the severity of HIV-associated dementia

A. Towfighi, MD, R. L. Skolasky, MA, C. St. Hillaire, BS, K. Conant, MD and J. C. McArthur, MBBS MPH

From the Department of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD.

Address correspondence and reprint requests to Dr. Justin McArthur, Johns Hopkins Hospital, 600 N. Wolfe St. Meyer 6-109, Baltimore, MD 21287; e-mail: jm{at}jhmi.edu

Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia (HIV-D). The authors investigated whether these markers correlated with dementia severity and course. sFas and sFasL were measured in 15 highly active antiretroviral therapy (HAART)-naïve HIV-D subjects, 30 HAART-naïve HIV+ controls, and 17 HIV-controls. HIV-D subjects had higher CSF sFas levels than controls. Subjects with moderate/severe dementia had higher CSF sFas levels than those with mild dementia. CSF sFas trended lower in those with progressive dementia.

Received May 23, 2002. Accepted in final form October 14, 2003.




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