| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Experimental Neuroimaging Section (Drs. Frank and Bash, B. Lewis), Laboratory of Diagnostic Radiology Research, and Neuroimmunology Branch (Drs. Richert and McFarland, R. Stone and T. Howard), National Institute for Neurological Disorders and Stroke, NIH, Uniformed Services University of Health Sciences (Dr. Bash), Bethesda, and Johns Hopkins University (Dr. Calabresi), Baltimore, MD, and Cleveland Clinic (Dr. Stone), OH.
Address correspondence and reprint requests to Dr. J.A. Frank, Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, 10 Center Drive, MSC 1074, Bldg. 10, Rm. B1N256, Bethesda, MD 20892-1074; e-mail: jafrank{at}helix.nih.gov
Objective: To determine the effect of interferon-ß-1b (IFNß-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing–remitting multiple sclerosis (RRMS) using serial monthly MRI.
Methods: An open-label baseline-vs-treatment crossover trial was conducted with 30 RRMS patients monitored during a 6-month baseline and up to 36 months on treatment with IFNß-1b. Monthly MRI exams and neurologic exams using the Expanded Disability Status Scale (EDSS) were performed.
Results: The percentage changes from baseline for years 1, 2, and 3 on IFNß-1b were as follows: brain volume (BV) = -1.35, -1.48, and -1.68%; CEL = -76.5, -60.1, and -54.7%; WMLL = -12.2, -9.8, and -10.4%. There was no difference in the BV, CEL, or WMLL for between-year comparisons, and the decrease in BV from year 1 to years 2 and 3 was less than the change from baseline to year 1. EDSS did increase (p < 0.001) when comparing the last 3 months of baseline (2.8 ± 2.1) and the last 3 months on IFNß-1b (3.6 ± 2.1). Eleven patients developed neutralizing antibody (NAb) during the study. The effect of IFNß-1b on CEL and WMLL was significantly reduced in NAb+ patients compared with NAb- patients (p < 0.003).
Conclusion: IFNß-1b decreases contrast-enhancing lesions and white matter lesion load over 3 years on therapy and slows the progression in cerebral atrophy during years 2 and 3.
Received July 2, 2003. Accepted in final form November 3, 2003.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 9 issue to find the title link for this article.
This article has been cited by other articles:
|
|
 |
|
  P. Soelberg Sorensen Review: Neutralizing antibodies against interferon-beta Therapeutic Advances in Neurological Disorders, September 1, 2008; 1(2): 125 - 141. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Zivadinov, A. T. Reder, M. Filippi, A. Minagar, O. Stuve, H. Lassmann, M. K. Racke, M. G. Dwyer, E. M. Frohman, and O. Khan Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis Neurology, July 8, 2008; 71(2): 136 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Yu, C. Z. Zhu, K. C. Li, Y. Xuan, W. Qin, H. Sun, and P. Chan Relapsing Neuromyelitis Optica and Relapsing-Remitting Multiple Sclerosis: Differentiation at Diffusion-Tensor MR Imaging of Corpus Callosum Radiology, July 1, 2007; 244(1): 249 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Goodin, E. M. Frohman, B. Hurwitz, P. W. O'Connor, J. J. Oger, A. T. Reder, and J. C. Stevens Neutralizing antibodies to interferon beta: Assessment of their clinical and radiographic impact: An evidence report: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology Neurology, March 27, 2007; 68(13): 977 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Simon Brain atrophy in multiple sclerosis: what we know and would like to know Multiple Sclerosis, November 1, 2006; 12(6): 679 - 687. [Abstract] [PDF]
|
|
|
|
|
|
N. D. Richert, T. Howard, J. A. Frank, R. Stone, J. Ostuni, J. Ohayon, C. Bash, and H. F. McFarland Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis Neurology, February 28, 2006; 66(4): 551 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Bermel, S. R. Puli, R. A. Rudick, B. Weinstock-Guttman, E. Fisher, F. E. Munschauer III, and R. Bakshi Prediction of Longitudinal Brain Atrophy in Multiple Sclerosis by Gray Matter Magnetic Resonance Imaging T2 Hypointensity Arch Neurol, September 1, 2005; 62(9): 1371 - 1376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Francis, G. P.A. Rice, J. C. Alsop, and for the PRISMS (Prevention of Relapses and Disabil Interferon {beta}-1a in MS: Results following development of neutralizing antibodies in PRISMS Neurology, July 12, 2005; 65(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Stuart, S. Cohan, J. R. Richert, and A. Achiron Selecting a disease-modifying agent as platform therapy in the long-term management of multiple sclerosis Neurology, December 14, 2004; 63(11_suppl_5): S19 - S27. [Abstract] [Full Text]
|
|
|
|
|
|
T. K. Vartanian, S. S. Zamvil, E. Fox, and P. S. Sorensen Neutralizing antibodies to disease-modifying agents in the treatment of multiple sclerosis Neurology, December 14, 2004; 63(11_suppl_5): S42 - S49. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
