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From the Department of Neurology (Drs. Katsarava, Fritsche, Eikermann, Diener, and Limmroth, U. Kroener), University Hospital Essen, Germany; and Divisions of Pharmacoepidemiology and Pharmacoeconomics (Dr. Schneeweiss) and Preventive Medicine and Aging (Dr. Kurth), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.
Address correspondence and reprint requests to Dr. V. Limmroth, Department of Neurology, University Hospital Essen, University of Essen, Hufelandstr. 55, 45122 Essen, Germany; e-mail: volker.limmroth{at}uni-essen.de
The authors followed 532 consecutive patients with episodic migraine (<15 days/month) for 1 year. Sixty-four patients (14%) developed chronic headache (
15 days/month). The odds ratios for developing CH were 20.1 (95% CI 5.7 to 71.5) comparing patients with a "critical" (10 to 14 days/month) vs "low" (0 to 4 days/month) and 6.2 (95% CI 1.7 to 26.6) in patients with an "intermediate" (6 to 9 days/month) vs "low" headache frequency and 19.4 (95% CI 8.7 to 43.2) comparing patients with and without medication overuse.
Received July 15, 2003. Accepted in final form October 6, 2003.
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