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NEUROLOGY 2004;62:809-810
© 2004 American Academy of Neurology
Brief Communications

TNF-376A marks susceptibility to MS in the Spanish population

A replication study

A. Martínez, PhD, A. Rubio, PhD, E. Urcelay, PhD, M. Fernández-Arquero, PhD, V. de las Heras, MD, R. Arroyo, MD, P. Villoslada, MD, X. Montalbán, MD, PhD and E.G. de la Concha, MD, PhD

From the Immunology Department (Drs. Martínez, Rubio, Urcelay, Fernández-Arquero, and de la Concha) and Multiple Sclerosis Unit (Drs. de las Heras and Arroyo), Neurology Department, Hospital Clinico San Carlos, Madrid, Spain; Multiple Sclerosis Center and Neuroimmunology Lab (Dr. Villoslada), Department of Neurology, Clinica Universitaria de Navarra, Spain; and Clinical Neuroimmunology Unit (Dr. Montalbán), Hospital Vall d’Hebron, Barcelona, Spain.

Address correspondence and reprint requests to Dr. Alfonso Martínez, Servicio de Inmunologia Clinica, Hospital Clinico San Carlos, C/Martín Lagos s/n., 28040 Madrid, Spain; e-mail: alfmdoncel{at}terra.es

This study was designed as a reappraisal of the association between the TNF-376A promoter polymorphism and susceptibility to multiple sclerosis found in the Spanish population but not in other populations. With a new dataset of patients (n = 241) and control subjects (n = 288), the association was confirmed (p = 0.018). The authors’ data suggest that this association is specific of the Spanish white (or related) population or, alternatively, that only studies in their population have the adequate statistical power because of the higher frequency of an extended, conserved haplotype carrying the TNF-376A allele.

Received August 4, 2003. Accepted in final form October 29, 2003.






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