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Association of APOE polymorphisms with disease severity in MS is limited to women

From the Departments of Neurology (Drs. Kantarci, Pittock, Rodriguez, and Weinshenker, D.D. Hebrink and J.L. Schaefer-Klein), Health Sciences Research (Dr. de Andrade, S.J. Achenbach and E.J. Atkinson), and Pharmacology, Biochemistry, and Molecular Biology and Molecular Neuroscience Program (Dr. McMurray), Mayo Clinic and Foundation, Rochester, MN; and Department of Neurology (Dr. Altintas), Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.

The authors studied the association of an exon 4 (E4*2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles 3 or 4 and promoter polymorphisms were not associated with disease course or severity.

Received May 30, 2003. Accepted in final form October 31, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 9 issue to find the link for this article.

Presented in part at the American Academy of Neurology Meeting; Honolulu, HI; March 29 to April 5, 2003.

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