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Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance

From the Department of Neurology, University of Crete, Medical School, Heraklion, Crete, Greece.

Address correspondence and reprint requests to Dr. Andreas Plaitakis, Professor and Chairman, Department of Neurology, University of Crete, Voutes, 71500 Heraklion, Crete, Greece; e-mail: plaitak{at}med.uoc.gr

The authors studied Parkinson disease (PD) in natives of Crete, a population sharing a common genetic and cultural background. Analysis of data from 247 index PD cases revealed a hereditary component for PD (OR 3.37; p < 0.001 for a first-degree relative of a PD patient). In 12 bilineal families (PD originating from both parental sides) identified, a high proportion (43%) of bilineal members had PD, but only 5.7% of their offspring were affected. These data suggest a recessive or an oligogenic inheritance for PD.

Received August 14, 2003. Accepted in final form October 28, 2003.

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