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NEUROLOGY 2004;62:821-824
© 2004 American Academy of Neurology
Brief Communications

Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barré syndrome

K. Kaida, MD, PhD, S. Kusunoki, MD, PhD, M. Kanzaki, MD, K. Kamakura, MD, PhD, K. Motoyoshi, MD, PhD and I. Kanazawa, MD, PhD

From the Third Department of Internal Medicine (Drs. Kaida, Kanzaki, Kamakura, and Motoyoshi), National Defense Medical College, Saitama-ken, Department of Neurology (Dr. Kusunoki), Kinki University School of Medicine, Osaka, and Department of Neurology (Dr. Kanazawa), School of Medicine, University of Tokyo, Japan.

Address correspondence and reprint requests to Dr. S. Kusunoki, Department of Neurology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, 589-8511 Japan; e-mail: kusunoki-tky{at}umin.ac.jp

Compared with 87 unventilated patients with Guillain-Barré syndrome (GBS), 44 ventilated patients with GBS more frequently had multiple cranial nerve involvement (91 vs 50%; p < 0.001) and IgG anti-GQ1b antibody (27 vs 8%; p = 0.006). In GBS patients without ophthalmoparesis, the presence of IgG anti-GQ1b antibody was associated with respiratory failure (12 [3/25] vs 0% [0/67]; p = 0.04). The presence of the antibody may be a factor predictive of respiratory failure in GBS.

Received January 23, 2003. Accepted in final form October 23, 2003.




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Correspondence:

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Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barré syndrome
Li Haifeng
Neurology Online, 19 Jun 2004 [Full text]
Reply to Haifeng
Susumu Kusunoki, et al.
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