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NEUROLOGY 2004;62:872-877
© 2004 American Academy of Neurology
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Cognitive side effects of antiepileptic drugs in children

David W. Loring, PhD and Kimford J. Meador, MD

From the Department of Neurology, Georgetown University Medical Center, Washington, DC.

Address correspondence and reprint requests to Dr. David W. Loring, Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road NW, Building D, Suite 207, Washington, DC 20057; e-mail: dwl7{at}georgetown.edu

Cognitive impairment associated with antiepileptic drug (AED) therapy in children is an important concern given the potential negative effects of treatment on school learning and performance. Unfortunately, there have been few studies examining the cognitive effects of AEDs in this population and no adequate studies of newer AEDs. This article will discuss the effects of the traditional and newer AEDs on neuropsychological function in children. Because of various limitations in the designs of these studies, however, many of the studies report inconclusive findings. Although it will be necessary to overcome many programmatic and procedural hurdles, well-designed randomized prospective studies that are of adequate length to determine how AEDs ultimately relate to school performance and social adjustment are needed to firmly establish the cognitive and behavioral effects of AEDs in children.

Received August 14, 2003. Accepted in final form November 26, 2003.




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