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NEUROLOGY 2004;62:968-970
© 2004 American Academy of Neurology
Brief Communications

Statin use and stroke outcomes in the Heart and Estrogen–Progestin Replacement Study (HERS)

C. D. Bushnell, MD MHS, L. K. Newby, MD MHS, L. B. Goldstein, MD, F. Lin, MS, K. Yaffe, MD and J. A. Simon, MD MPH

From the Department of Medicine (Neurology) (Drs. Bushnell and Goldstein), Duke Center for Cerebrovascular Disease (Drs. Bushnell and Goldstein), Division of Cardiology and Duke Clinical Research Institute (Dr. Newby), and Center for Clinical Health Policy Research (Dr. Goldstein), Duke University Medical Center, and VA Medical Center (Dr. Goldstein), Durham, NC, and Departments of Epidemiology and Biostatistics (F. Lin) and Neurology and Psychiatry (Dr. Yaffe), University of California at San Francisco, and General Internal Medicine Section (Dr. Simon), San Francisco VA Medical Center, CA.

Address correspondence and reprint requests to Dr. C. Bushnell, Duke University Medical Center, Box 2900, Durham, NC 27710; e-mail: Cheryl.Bushnell{at}duke.edu

The authors investigated the relationship between statin use and the risk of stroke in the Heart and Estrogen–Progestin Replacement Study (HERS). Despite large reductions in relative risk point estimates, statin use was not associated with differences in the risks of all fatal stroke (relative hazard [RH] 0.52, 95% CI 0.23 to 1.18, p = 0.12), fatal ischemic stroke (RH 0.51, 95% CI 0.18 to 1.45, p = 0.21), fatal hemorrhagic stroke (RH 0.18, 95% CI 0.02 to 1.46, p = 0.11), or TIA (RH 1.32, 95% CI 0.84 to 2.09, p = 0.23).

Received July 8, 2003. Accepted in final form November 18, 2003.




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