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NEUROLOGY 2004;62:981-983
© 2004 American Academy of Neurology
Brief Communications

Reversible diffusion MRI abnormalities and transient mutism after liver transplantation

F. Bianco, MD, F. Fattapposta, MD, N. Locuratolo, MD, A. Pierallini, MD, M. Rossi, MD, F. Ruberto, MD and L. Bozzao, MD

From the Departments of Neurology and Otolaryngology (Drs. Fattapposta and Locuratolo), Neuroradiology Unit (Dr. Bianco), Neurological Sciences, Neuroradiology Unit (Drs. Pierallini and Bozzao), and General Surgery and Transplantation (Drs. Rossi and Ruberto), University of Rome "La Sapienza," Italy.

Address correspondence and reprint requests to Dr. Federico Bianco, Associate Professor, Servizio Aggregato di Neuroradiologia, Dipartimento di Neurologia e Otorinolaringoiatria, Università degli Studi di Roma "La Sapienza," Viale dell’Università n.30, 00185 Rome, Italy; e-mail: federico.bianco{at}uniroma1.it

Transient mutism was observed in a liver transplant patient under immunosuppressant therapy with cyclosporine A and antifungal prophylaxis with amphotericin B. Fluid-attenuated inversion recovery and diffusion-weighted images revealed reversible bilateral symmetric hyperintensity located in the frontal motor cortex and corticospinal tracts. These MRI abnormalities may be caused by acute edema, possibly a combination of cytotoxic and vasogenic edema, which resolved with a prompt change in therapy.

Received September 10, 2003. Accepted in final form November 26, 2003.




This article has been cited by other articles:


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M. R. Turner, F. Bianco, F. Fattapposta, N. Locuratolo, A. Pierallini, F. Ruberto, M. Rossi, and L. Bozzao
Reversible diffusion MRI abnormalities and transient mutism after liver transplantation
Neurology, January 11, 2005; 64(1): 177 - 177.
[Full Text] [PDF]

Correspondence:

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Reversible diffusion MRI abnormalities and transient mutism after liver transplantation
Martin R Turner
Neurology Online, 26 Jul 2004 [Full text]
Reply to Turner
Federico Bianco, et al.
Neurology Online, 26 Jul 2004 [Full text]

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