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NEUROLOGY 2004;62:1190-1192
© 2004 American Academy of Neurology
Brief Communications

Alpha-1-antitrypsin deficiency alleles are not associated with cervical artery dissections

C. Grond-Ginsbach, PhD, S. Engelter, MD, I. Werner, I. Hausser, PhD, U. S. Müller, MD, T. Brandt, MD and P. Lyrer, MD

From the Departments of Neurology (Drs. Grond-Ginsbach and Werner) and Dermatology (Dr. Hausser), University of Heidelberg, Germany; Stroke Unit (Drs. Engelter and Lyrer), University Hospital Basel, Switzerland; and Schmieder Kliniken Heidelberg (Drs. Mueller and Brandt), Germany.

Address correspondence and reprint requests to Dr. Casper Grond-Ginsbach, Neurology Department, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg D-69120, Germany; e-mail: caspar_grond-ginsbach{at}med.uni-heidelberg.de

The authors searched for the presence of {alpha}-1-antitrypsin (AAT) deficiency alleles PiZ and PiS in 74 patients with spontaneous cervical artery dissections (sCADs) and in 74 healthy control subjects. In both groups, the authors found four carriers of deficiency alleles. The connective tissue morphology of one additional patient with sCAD with PiZM genotype and her relatives was studied in skin biopsies. The PiZ allele did not segregate with morphologic alterations of the dermal connective tissue in the family. Therefore, AAT deficiency alleles may not play a role in the etiology of sCAD.

Received June 18, 2003. Accepted in final form November 26, 2003.






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