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NEUROLOGY 2004;62:1193-1195
© 2004 American Academy of Neurology
Brief Communications

Feasibility and safety of norepinephrine-induced arterial hypertension in acute ischemic stroke

A. S. Marzan, H. -J. Hungerbühler, MD, A. Studer, MD, R. W. Baumgartner, MD and D. Georgiadis, MD

From the Department of Neurology (Drs. Studer, Baumgartner, and Georgiadis, A.S. Marzan), University of Zürich, Switzerland; and Cantonal Hospital of Aarau (Dr. Hungerbühler), Switzerland.

Address correspondence and reprint requests to Dr. D. Georgiadis, Department of Neurology, University of Zürich, Frauenklinikstr. 26, 8091 Zürich, Switzerland; e-mail: dimitrios.georgiadis{at}usz.ch

The feasibility and safety of induced arterial hypertension (10 to 20% of the initial value) in the acute phase of ischemic stroke were retrospectively evaluated in 34 patients treated with norepinephrine (NE) for a median of 26 hours. Maximal variability of systolic blood pressure during NE application was within 15% of the target values. Cardiac arrhythmia occurred in one patient, and intracerebral hemorrhage occurred in two patients (fatal in one and asymptomatic in the other). The authors conclude that induced arterial hypertension is feasible and safe in patients with acute stroke.

Received July 11, 2003. Accepted in final form December 10, 2003.




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