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NEUROLOGY 2004;62:1196-1198
© 2004 American Academy of Neurology
Brief Communications

The impact of APOE on myocardial infarction, stroke, and dementia

The Rotterdam Study

A.J. C. Slooter, MD PhD, M. Cruts, PhD, A. Hofman, MD PhD, P. J. Koudstaal, MD PhD, D. van der Kuip, MD PhD, M.A. J. de Ridder, MSc, J.C. M. Witteman, PhD, M.M. B. Breteler, MD PhD, C. Van Broeckhoven, PhD and C. M. van Duijn, PhD

From the Departments of Epidemiology & Biostatistics (Drs. Slooter, Hofman, van der Kuip, Witteman, Breteler, and van Duijn, and M.A.J. de Ridder) and Neurology (Dr. Koudstaal), Erasmus Medical Center, Rotterdam, the Netherlands; Molecular Genetics Laboratory (Drs. Cruts and Van Broeckhoven), Flanders Interuniversity Institute for Biotechnology (VIB), Born-Bunge Foundation (BBS), Department of Biochemistry, University of Antwerp (UIA), Antwerpen, Belgium; and Rudolf Magnus Institute of Neurosciences (Dr. Slooter), Department of Neurology, University Medical Center, Utrecht, the Netherlands.

Address correspondence and reprint requests to Dr. Cornelia M. van Duijn, Department of Epidemiology & Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, the Netherlands; e-mail: c.vanduijn{at}erasmusmc.nl

It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of {epsilon}4, the incidence of dementia would be 25.8% lower; in the absence of {epsilon}2/{epsilon}3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

Received April 5, 2003. Accepted in final form November 13, 2003.




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