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Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease

From the Department of Molecular Neurosciences (Drs. Khan, Wood, and Lees) and Sobell Department of Motor Neuroscience and Movement Disorders (Drs. Bhatia and Quinn), Institute of Neurology, Reta Lila Weston Institute of Neurological Studies (Drs. Katzenschlager and Lees), Royal Free Hospital and University College Medical School, and Department of Statistics (H. Watt), London School of Hygiene and Tropical Medicine, University College London, UK.

Address correspondence and reprint requests to Dr. A.J. Lees, Reta Lila Weston Institute of Neurological Studies, Royal Free Hospital and University College Medical School, Windeyer Bldg., 46 Cleveland St., London W1P 6DB, UK; e-mail: a.lees{at}ion.ucl.ac.uk

The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p = 0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.

Received November 22, 2002. Accepted in final form December 2, 2003.

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