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NEUROLOGY 2004;62:1402-1404
© 2004 American Academy of Neurology
Brief Communications

Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies

D. J.H. McCabe, MRCPI, N. C. Turner, MRCP, D. Chao, MRCP, A. Leff, MRCP, N. A. Gregson, PhD, H. J. Womersley, BSc, I. Mak, FRCP, G. D. Perkin, FRCP and A. H.V. Schapira, FRCP

From the University Department of Clinical Neurosciences (Drs. McCabe, Leff, and Schapira), Royal Free and University College, Medical School, and The Department of Oncology (Drs. Turner and Chao), The Royal Free Hospital Hampstead; Institute of Neurology (Drs. McCabe and Schapira), The National Hospital for Neurology and Neurosurgery, University College London, Queen Square; Department of Neuroimmunology (Dr. Gregson and H.J. Womersley), Hodgkin Building, Guy’s Campus, London Bridge; and West London Neurosciences Centre (Drs. Mak and Perkin), Charing Cross Hospital, London, UK.

Address correspondence and reprint requests to Dr. Dominick J.H. McCabe, Stroke Research Unit, Department of Headache, Brain Injury and Rehabilitation, Box 6, Institute of Neurology, The National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3BG UK; e-mail: d.mccabe{at}ion.ucl.ac.uk

A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.

Received January 6, 2003. Accepted in final form November 13, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the April 27 issue to find the title link for this article.




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