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NEUROLOGY 2004;62:1611-1612
© 2004 American Academy of Neurology
Brief Communications

HFE mutations are not strongly associated with sporadic ALS

A. A. Yen, MD, E. P. Simpson, MD, J. S. Henkel, PhD, D. R. Beers, PhD and S. H. Appel, MD

From the Department of Neurology, Baylor College of Medicine, Houston, TX.

Address correspondence and reprint requests to Dr. S.H. Appel, 6501 Fannin, NB 302, Houston, TX 77030; e-mail: sappel{at}bcm.tmc.edu

The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress. The prevalence of the C282Y and H63D mutations was nearly identical in 51 ALS patients and 47 normal control subjects. The presence of either mutation did not significantly affect the age at onset or rate of progression in ALS.

Received November 7, 2003. Accepted in final form December 23, 2003.




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