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Genes influencing Parkinson disease onset

Replication of PARK3 and identification of novel loci

From the Department of Medical and Molecular Genetics (Drs. Pankratz, Conneally, and Foroud, C.A. Halter), Indiana University Medical Center, Indianapolis, IN; Division of Human Genetics (Dr. Nichols, S.K. Uniacke), Cincinnati Children’s Hospital Medical Center, OH; Department of Neurology (Dr. Rudolph), University of Rochester, NY; and Department of Neurosciences (Dr. Shults), University of California, La Jolla, and VA San Diego Healthcare System, CA.

Address correspondence and reprint requests to Dr. W.C. Nichols, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., 1469 TCHRF, Cincinnati, OH 45229; e-mail: bill.nichols{at}cchmc.org

A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

Received September 16, 2003. Accepted in final form December 30, 2003.

*See the Appendix on page 1618 for a list of Group members.

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