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NEUROLOGY 2004;62:1631-1633
© 2004 American Academy of Neurology
Brief Communications

Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism

D. Seripa, PhD, M. G. Matera, PhD, R. P. D’Andrea, BSc, C. Gravina, BSc, C. Masullo, MD, A. Daniele, MD, A. Bizzarro, MD, M. Rinaldi, PhD, P. Antuono, MD, D. R. Wekstein, MD, G. Dal Forno, MD and V. M. Fazio, MD

From the Laboratory of Gene Therapy (Drs. Seripa, Matera, and Fazio, R.P. D’Andrea and C. Gravina), IRCCS "Casa Sollievo della Sofferenza," San Giovanni Rotondo (FG), Institute of Neurology (Drs. Masullo, Daniele, and Bizzarro), Catholic University School of Medicine, and Gene Medicine Division (Dr. Rinaldi), Molecular Medicine Section, Institute of Neurobiology and Molecular Medicine, CNR, and Clinical Neurology (Dr. Dal Forno) and Laboratory for Molecular Medicine and Biotechnology (Dr. Fazio), Interdisciplinary Center for Biomedical Research, University Campus Bio-Medico, Rome, Italy; and Department of Neurology (Dr. Antuono), Medical College of Wisconsin, Milwaukee, Alzheimer’s Disease Research Center (Dr. Wekstein), University of Kentucky, Lexington, and Department of Neurology (Dr. Dal Forno), Johns Hopkins University School of Medicine, Baltimore, MD.

Address correspondence and reprint requests to Dr. D. Seripa, Laboratory of Gene Therapy, IRCCS "Casa Sollievo della Sofferenza," Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo (FG) I-71013, Italy; e-mail: dseripa{at}operapadrepio.it

The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.

Received December 4, 2003. Accepted in final form February 23, 2004.




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