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NEUROLOGY 2004;62:1634-1636
© 2004 American Academy of Neurology
Brief Communications

Serum S100ß increases in marathon runners reflect extracranial release rather than glial damage

M. Hasselblatt, MD, F. C. Mooren, MD, N. von Ahsen, MD, K. Keyvani, MD, A. Fromme, MD, K. Schwarze-Eicker, MD, V. Senner, PhD and W. Paulus, MD

From the Institutes of Neuropathology (Drs. Hasselblatt, Keyvani, Schwarze-Eicker, Senner, and Paulus) and Sports Medicine (Drs. Mooren and Fromme), University Hospital Münster, Germany; and Department of Clinical Chemistry (Dr. von Ahsen), Georg-August University, Göttingen, Germany.

Address correspondence and reprint requests to Dr. Martin Hasselblatt, Institute of Neuropathology, University Hospital Münster, Domagkstr. 19, D-48129 Münster, Germany; e-mail: hasselblatt{at}uni-muenster.de

The contribution of extracranial tissue damage to serum S100ß increases was examined in 18 marathon runners without clinical or laboratory signs of brain damage. Postrace serum S100ß and creatine kinase (CK) concentrations increased (p < 0.001), and areas under the curve were highly correlated (p = 0.001). To conclude, serum S100ß increases after running originate from extracranial sources. CK determination may improve specificity of S100ß as a marker of brain tissue damage in acute trauma.

Received October 17, 2003. Accepted in final form December 23, 2003.




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