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NEUROLOGY 2004;62:1639-1642
© 2004 American Academy of Neurology
Brief Communications

Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics

Emily R. Edwards, BA, Karla Lindquist, MS and Kristine Yaffe, MD

From the Departments of Psychiatry (Dr. Yaffe, E.R. Edwards), Neurology (Dr. Yaffe), and Epidemiology (Dr. Yaffe) and Division of Geriatrics (K. Lindquist), University of California, San Francisco, and San Francisco VA Medical Center (Dr. Yaffe, E.R. Edwards).

Address correspondence and reprint requests to Dr. K. Yaffe, 4150 Clement St., 181G, San Francisco, CA 94121; e-mail: kyaffe{at}itsa.ucsf.edu

The authors investigated 499 patients that were found to be cognitively normal at the Alzheimer’s Disease Research Centers of California between 1988 and 1999. Patients reported high rates of depression (39%) and family history of dementia (51%). Thirty-six percent returned for follow-up, and of those, 65% received a diagnosis of dementia or mild cognitive impairment. Patients evaluated at memory clinics who are considered cognitively normal may merit periodic re-evaluation.

Received August 22, 2003. Accepted in final form January 8, 2004.




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