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NEUROLOGY 2004;63:153-155
© 2004 American Academy of Neurology
Brief Communications

L-Dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction

H. Russmann, MD, J. Ghika, MD, P. Combrement, MD, J. G. Villemure, MD, J. Bogousslavsky, MD, P. R. Burkhard, MD and F. J.G. Vingerhoets, MD

From the Departments of Neurology (Drs. Russmann, Ghika, Combrement, Bogousslavsky, and Vingerhoets) and Neurosurgery (Dr. Villemure), Lausanne; and Department of Neurology (Dr. Burkhard), HUG, Geneva, Switzerland.

Address correspondence and reprint requests to Dr. F. Vingerhoets, Department of Neurology, CHUV, BH13, Route de Bugnon 11, CH-1011 Lausanne, Switzerland; e-mail: francois.vingerhoets{at}chuv.hospvd.ch

The authors studied the long-term evolution of levodopa-induced dyskinesia (LID) after levodopa challenge in two groups of six STN-deep brain stimulation-treated Parkinson disease (PD) patients, one requiring medication after surgery and the other not. A dramatic (96%) reduction of LID severity was obtained in the six postoperatively untreated patients compared to a moderate improvement (47%) in the treated group (p < 0.03). These data support dopaminergic stimulation and striatal desensitization as major determinants of LID in PD.

Received July 14, 2003. Accepted in final form January 8, 2004.




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