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NEUROLOGY 2004;63:156-158
© 2004 American Academy of Neurology
Brief Communications

Anti-basal ganglia antibodies in patients with atypical dystonia and tics

A prospective study

M. J. Edwards, MBBS, E. Trikouli, MD, D. Martino, MD, M. Bozi, MD, R. C. Dale, MBBS, A. J. Church, PhD, A. Schrag, MD, A. J. Lees, MD, N. P. Quinn, MD, G. Giovannoni, PhD and K. P. Bhatia, MD

From the Sobell Department of Motor Neuroscience and Movement Disorders (M.J. Edwards, and Drs. Trikouli, Bozi, Schrag, Quinn, and Bhatia) and Neuroimmunology Unit, Department of Neuroinflammation (Drs. Martino, Church, and Giovannoni, and R.C. Dale), Institute of Neurology, UCL, Queen Square, London; Department of Neurological and Psychiatric Sciences (Dr. Martino), University of Bari, Italy; Neurosciences Unit (R.C. Dale), Institute of Child Health, London; and The Reta Lila Weston Institute of Neurological Studies (Dr . Lees), London, UK.

Address correspondence and reprint requests to Dr. K. Bhatia, Reader in Clinical Neurology, Sobell Dept. of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; e-mail: k.bhatia{at}ion.ucl.ac.uk

Anti-basal ganglia antibodies (ABGA) are associated with movement disorders in children, but have not been assessed in adult onset movement disorders. In a prospective assessment ABGA were positive in 65% of a group of 65 patients with atypical movement disorders, but were very rare in healthy adults and adults with idiopathic dystonia. An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders.

Received November 20, 2003. Accepted in final form February 23, 2004.




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