HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, S. -H. Articles by Yoon, B. W. Search for Related Content PubMed PubMed Citation Articles by Lee, S. -H. Articles by Yoon, B. W. Related Collections All Cerebrovascular disease/Stroke Cardiac All epidemiology Risk factors in epidemiology Intracerebral hemorrhage

Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients

From the Department of Neurology (Drs. Lee, Park, Kwon, Roh, and Yoon), Department of Epidemiology and Biostatistics and Institute of Public Health (Drs. H. Kim and Y.-H. Kim), School of Public Health, and Neuroscience Research Institute (Drs. Lee, Park, Kwon, Roh, and Yoon), SNUMRC and Clinical Research Institute, Seoul National University Hospital, Republic of Korea.

Address correspondence and reprint requests to Dr. B.-W.Yoon, Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea; e-mail: bwyoon{at}snu.ac.kr

Background: Cerebral microbleeds (CMBs) are indicative of hemorrhage-prone microangiopathy and known to be closely associated with chronic hypertension. However, no studies have been undertaken on the association between left ventricular (LV) hypertrophy and the severity of CMB.

Methods: One hundred two consecutive stroke patients with hypertension were examined. CMBs were counted using T2*-weighted gradient echo MRI data. With use of ordinal logistic regression analysis, the associations between LV mass index and other vascular risk factors and CMBs were analyzed.

Results: Hypertensive patients with CMBs showed a higher LV mass index than patients without. The grades of LV mass index were significantly correlated with the grades of CMB in the whole brain (p = 0.02), in the central gray matter (p < 0.01), and in the infratentorial area (p < 0.01), but not with those in the subcortical white matter. Ordinal regression analysis revealed that the LV mass index was independently associated with increased CMB severity (p = 0.01), regionally in the central gray matter (p < 0.01) and in the infratentorial area (p < 0.01), but not in the subcortical white matter (p = 0.63). After excluding patients with cerebral amyloid angiopathy, the association between the LV mass index and the CMB severity in the subcortical white matter became significant (p < 0.01).

Conclusions: There is a close relationship between CMBs and LV hypertrophy in hypertensive patients with stroke. Thus, CMBs should be understood as one type of cerebral target organ damage by chronic hypertension.

Received October 12, 2003. Accepted in final form March 11, 2004.

See also page 6

This article has been cited by other articles:

				C. Cordonnier, G. M. Potter, C. A. Jackson, F. Doubal, S. Keir, C. L.M. Sudlow, J. M. Wardlaw, and R. A.-S. Salman Improving Interrater Agreement About Brain Microbleeds: Development of the Brain Observer MicroBleed Scale (BOMBS) Stroke, January 1, 2009; 40(1): 94 - 99. [Abstract] [Full Text] [PDF]

				Y. Yakushiji, M. Nishiyama, S. Yakushiji, T. Hirotsu, A. Uchino, J. Nakajima, M. Eriguchi, Y. Nanri, M. Hara, E. Horikawa, et al. Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder Stroke, December 1, 2008; 39(12): 3323 - 3328. [Abstract] [Full Text] [PDF]

				S-H Lee, B-S Kang, N Kim, and J-K Roh Does microbleed predict haemorrhagic transformation after acute atherothrombotic or cardioembolic stroke? J. Neurol. Neurosurg. Psychiatry, August 1, 2008; 79(8): 913 - 916. [Abstract] [Full Text] [PDF]

				L. H.G. Henskens, R. J. van Oostenbrugge, A. A. Kroon, P. W. de Leeuw, and J. Lodder Brain Microbleeds Are Associated With Ambulatory Blood Pressure Levels in a Hypertensive Population Hypertension, January 1, 2008; 51(1): 62 - 68. [Abstract] [Full Text] [PDF]

				C. Cordonnier, R. Al-Shahi Salman, and J. Wardlaw Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting Brain, August 1, 2007; 130(8): 1988 - 2003. [Abstract] [Full Text] [PDF]

				A. Viswanathan, J.-P. Guichard, A. Gschwendtner, F. Buffon, R. Cumurcuic, C. Boutron, E. Vicaut, M. Holtmannspotter, C. Pachai, M.-G. Bousser, et al. Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study Brain, September 1, 2006; 129(9): 2375 - 2383. [Abstract] [Full Text] [PDF]

				S.-H. Lee, B. J. Kim, and J.-K. Roh Silent microbleeds are associated with volume of primary intracerebral hemorrhage Neurology, February 14, 2006; 66(3): 430 - 432. [Abstract] [Full Text] [PDF]

				A. Viswanathan and H. Chabriat Cerebral Microhemorrhage Stroke, February 1, 2006; 37(2): 550 - 555. [Abstract] [Full Text] [PDF]

				H.-C. Koennecke Cerebral microbleeds on MRI: Prevalence, associations, and potential clinical implications Neurology, January 24, 2006; 66(2): 165 - 171. [Abstract] [Full Text] [PDF]

				J. Rosand Hypertension and the brain: Stroke is just the tip of the iceberg Neurology, July 13, 2004; 63(1): 6 - 7. [Full Text] [PDF]