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NEUROLOGY 2004;63:164-166
© 2004 American Academy of Neurology
Brief Communications

Near-infrared spectrophotoscopy of finger venules in assessment of autonomic dysfunction

K. Obayashi, MD, Y. Ando, MD PhD, M. Nakamura, MD, T. Yamashita, MD, M. Ueda, MD, K. Haraoka, MD, H. Terazaki, MD and M. Uchino, MD

From the Departments of Neurology (Drs. Obayashi, Yamashita, and Ueda), Laboratory Medicine (Drs. Ando and Nakamura), and Gastroenterology (Drs. Haraoka, Terazaki, and Uchino), Kumamoto University School of Medicine, Japan.

Address correspondence and reprint requests to Dr. Y. Ando, Department of Laboratory Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-0811, Japan; e-mail: yukio{at}kaiju.medic.kumamoto-u.ac.jp

The authors evaluated morphologic changes in the venules of the finger using near-infrared spectrophotoscopy in patients with autonomic dysfunction, such as familial amyloidotic polyneuropathy and multiple-system atrophy. Abnormalities of the venules, such as tortuosity, irregular venous caliber, and microaneurysm-like change, and a linear negative correlation between the degree of orthostatic hypotension and the degree of vasoconstriction of the venules were observed.

Received July 22, 2003. Accepted in final form March 11, 2004.




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