Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inglese, M.
Right arrow Articles by Gonen, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inglese, M.
Right arrow Articles by Gonen, O.
Related Collections
Right arrow MRI
Right arrow MRS
Right arrow Multiple sclerosis
NEUROLOGY 2004;63:170-172
© 2004 American Academy of Neurology
Brief Communications

Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing–remitting MS

M. Inglese, MD, S. Liu, MD, J. S. Babb, PhD, L. J. Mannon, BSRT, R. I. Grossman, MD and O. Gonen, PhD

From the Department of Radiology, New York University School of Medicine, New York.

Address correspondence and reprint requests to Dr. O. Gonen, Department of Radiology, NYU School of Medicine, 550 1st Ave., New York, NY 10016; e-mail: oded.gonen{at}med.nyu.edu

The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing–remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub–cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).

Received December 9, 2003. Accepted in final form February 23, 2004.




This article has been cited by other articles:


Home page
 NeurologyHome page
U. Walter, S. Wagner, S. Horowski, R. Benecke, and U. K. Zettl
Transcranial brain sonography findings predict disease progression in multiple sclerosis
Neurology, September 29, 2009; 73(13): 1010 - 1017.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. Tovar-Moll, I.E. Evangelou, A.W. Chiu, N.D. Richert, J.L. Ostuni, J.M. Ohayon, S. Auh, M. Ehrmantraut, S.L. Talagala, H.F. McFarland, et al.
Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T
AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1380 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
B Holst, S Siemonsen, J Finsterbusch, M Bester, S Schippling, R Martin, and J Fiehler
T2' imaging indicates decreased tissue metabolism in frontal white matter of MS patients
Multiple Sclerosis, June 1, 2009; 15(6): 701 - 707.
[Abstract] [PDF]

Home page
 NeurologyHome page
S. Mesaros, M. A. Rocca, M. Absinta, A. Ghezzi, N. Milani, L. Moiola, P. Veggiotti, G. Comi, and M. Filippi
Evidence of thalamic gray matter loss in pediatric multiple sclerosis
Neurology, March 25, 2008; 70(13_Part_2): 1107 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. De Stefano, M. Filippi, D. Miller, P. J. Pouwels, A. Rovira, A. Gass, C. Enzinger, P. M. Matthews, and D. L. Arnold
Guidelines for using proton MR spectroscopy in multicenter clinical MS studies
Neurology, November 13, 2007; 69(20): 1942 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. P. Amato, E. Portaccio, B. Goretti, V. Zipoli, M. Battaglini, M. L. Bartolozzi, M. L. Stromillo, L. Guidi, G. Siracusa, S. Sorbi, et al.
Association of Neocortical Volume Changes With Cognitive Deterioration in Relapsing-Remitting Multiple Sclerosis
Arch Neurol, August 1, 2007; 64(8): 1157 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Inglese, S.-J. Park, G. Johnson, J. S. Babb, L. Miles, H. Jaggi, J. Herbert, and R. I. Grossman
Deep Gray Matter Perfusion in Multiple Sclerosis: Dynamic Susceptibility Contrast Perfusion Magnetic Resonance Imaging at 3 T
Arch Neurol, February 1, 2007; 64(2): 196 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
S D Brass, R H. Benedict, B Weinstock-Guttman, F Munschauer, and R Bakshi
Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
Multiple Sclerosis, August 1, 2006; 12(4): 437 - 444.
[Abstract] [PDF]

Home page
 BrainHome page
Z. Caramanos, S. Narayanan, and D. L. Arnold
1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review
Brain, November 1, 2005; 128(11): 2483 - 2506.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
G R Davies, D R Altmann, W Rashid, D T Chard, C M Griffin, G J Barker, R Kapoor, A J Thompson, and D H Miller
Emergence of thalamic magnetization transfer ratio abnormality in early relapsing--remitting multiple sclerosis
Multiple Sclerosis, June 1, 2005; 11(3): 276 - 281.
[Abstract] [PDF]