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Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing–remitting MS

From the Department of Radiology, New York University School of Medicine, New York.

Address correspondence and reprint requests to Dr. O. Gonen, Department of Radiology, NYU School of Medicine, 550 1st Ave., New York, NY 10016; e-mail: oded.gonen{at}med.nyu.edu

The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing–remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub–cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).

Received December 9, 2003. Accepted in final form February 23, 2004.

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